Palmitoylation and the trafficking of peripheral membrane proteins. (29th January 2013)

• Record Type: Journal Article
• Authors: Chamberlain, Luke H.; Lemonidis, Kimon; Sanchez-Perez, Maria; Werno, Martin W.; Gorleku, Oforiwa A.; Greaves, Jennifer
• Is Part Of: Biochemical Society transactions. Volume 41:Number 1(2013)
• Page Start: 62
• Page End: 66
• Publication Date: 2013-01-29
• Subjects: cysteine-string protein -- DHHC protein -- palmitoylation -- 25 kDa synaptosome-associated protein (SNAP25); Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20120243
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Palmitoylation, the attachment of palmitate and other fatty acids on to cysteine residues, is a common post-translational modification of both integral and peripheral membrane proteins. Dynamic palmitoylation controls the intracellular distribution of peripheral membrane proteins by regulating membrane–cytosol exchange and/or by modifying the flux of the proteins through vesicular transport systems.