Structural insights into the evolution of the pantothenate-biosynthesis pathway. (1st June 2003)

• Record Type: Journal Article
• Authors: Lobley, C.M.C.; Schmitzberger, F.; Kilkenny, M.L.; Whitney, H.; Ottenhof, H.H.; Chakauya, E.; Webb, M.E.; Birch, L.M.; Tuck, K.L.; Abell, C.; Smith, A.G.; Blundell, T.L.
• Is Part Of: Biochemical Society transactions. Volume 31:Number 3(2003)
• Page Start: 563
• Page End: 571
• Publication Date: 2003-06-01
• Subjects: enzyme pathway -- evolution -- pantothenate -- X-ray crystallography; Biochemistry -- Congresses; 572
• DOI: 10.1042/bst0310563
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Pantothenate is synthesized in bacteria, fungi and plants, and as vitamin B5 is a dietary requirement in animals. The three-dimensional structures of the four Escherichia coli enzymes involved in the production of pantothenate have been determined. We describe the use of comparative analyses of the sequences and structures to identify distant homologues of the four enzymes in an attempt to understand the evolution of the pathway. We conclude that it is likely to have evolved via a patchwork mechanism, whereby the individual enzymes were recruited separately.