Rrp47 and the function of the Sas10/C1D domain. (26th July 2010)

• Record Type: Journal Article
• Authors: Mitchell, Phil
• Is Part Of: Biochemical Society transactions. Volume 38:Number 4(2010)
• Page Start: 1088
• Page End: 1092
• Publication Date: 2010-07-26
• Subjects: C1D -- Lcp5 -- neuroguidin -- Rrp47 -- Rrp6 -- Sas10; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0381088
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The Sas10/C1D domain is found in a small group of eukaryotic proteins that have functions in RNA processing events, translational control and DNA repair mechanisms. The domain is predicted to be α-helical in nature and comprises approx. 80 amino acid residues. Whereas the Sas10/C1D domain has yet to be functionally characterized, available results suggest that this domain forms a binding surface for specific interactions with other proteins and can concomitantly interact with RNA or DNA. This property of the Sas10/C1D domain may facilitate this family of proteins to dock other proteins on to nucleic acid substrates.