Community-acquired Klebsiella pneumoniae central nervous system infection after acute suppurative otitis. (2021)

• Record Type: Journal Article
• Authors: Sun, Ruixue; Zhang, Hui; Xu, Yingchun; Zhu, Huadong; Yu, Xuezhong; Xu, Jun
• Is Part Of: IDCases. Volume 23(2020)
• Publication Date: 2021
• Subjects: K.pneumoniae Klebsiella pneumoniae -- CNS central nervous system -- CSF cerebrospinal fluid -- ILAS invasive liver abscess syndrome -- IRB Institutional Review Board; Klebsiella -- Pneumoniae -- Meningitis -- Brain abscesses -- Acute suppurative otitis -- Case report; Communicable diseases -- Periodicals; Communicable Diseases -- Case Reports; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; 616.9
• DOI: 10.1016/j.idcr.2020.e01016
• Languages: English
• ISSNs: 2214-2509

Abstract

Abstract: Community-acquired Klebsiella pneumoniae (K. pneumoniae) central nervous system (CNS) infection combined with bacteremia is rarely identified worldwide. We received a 55-year-old woman on long-term corticosteroid therapy for Sjogren's syndrome. Onset began with acute suppurative otitis, followed by a severe headache and loss of consciousness. Cerebrospinal fluid (CSF) testing and brain imaging examinations were compatible with K. pneumoniae meningitis and likely brain abscesses, respectively. K. pneumoniae bacteremia was also found on blood cultures. Despite aggressive antibiotic and supportive therapy, the patient died after 2 day's therapy. Corticosteroid therapy may be a risk factor for a community-acquired K. pneumoniae infection. Appropriate antibiotics and abscess drainage are still recommended, despite the poor prognosis.