Complex Roles of CpG in Liposomal Delivery of DNA and Oligonucleotides. Issue 2 (April 2002)

• Record Type: Journal Article
• Authors: Wilson, Annette; Pitt, Bruce; Li, Song
• Is Part Of: Bioscience reports. Volume 22:Issue 2(2002)
• Page Start: 309
• Page End: 322
• Publication Date: 2002-04
• Subjects: CpG motif -- immunostimulation -- oligonucleotide -- bacterial DNA -- liposome; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1023/A:1020146924504
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Unmethylated CpG in bacterial DNA has recently been recognized as a danger signal to the mammalian immune system. This CpG signal can be greatly amplified when DNA is delivered via a lipidic vector. The CpG effects are affected by the administration route, and can be either beneficial or harmful. In this review, we will summarize our current understanding about the mechanism of action of the immunostimulatory motifs. Emphasis will be placed on the discussion of the complicated roles of CpG when CpG DNA or oligonucleotides are administered in vivo using liposomes as a delivery vehicle.