The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses. (25th October 2006)

• Record Type: Journal Article
• Authors: Borroni, E.M.; Buracchi, C.; de la Torre, Y. Martinez; Galliera, E.; Vecchi, A.; Bonecchi, R.; Mantovani, A.; Locati, M.
• Is Part Of: Biochemical Society transactions. Volume 34:Number 6(2006)
• Page Start: 1014
• Page End: 1017
• Publication Date: 2006-10-25
• Subjects: CC chemokine receptor (CCR) -- chemoattractant -- decoy receptor -- Duffy antigen -- inflammation -- leucocyte; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0341014
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Other than signalling receptors sustaining leucocyte recruitment during inflammatory reactions, the chemokine system includes 'silent' receptors with distinct specificity and tissue distribution. The best-characterized molecule of this subgroup is the CC chemokine receptor D6, which binds most inflammatory CC chemokines and targets them to degradation via constitutive ligand-independent internalization. Structure–function analysis and recent results with gene-targeted animals indicate that D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium and placenta to dampen inflammation in tissues and draining lymph nodes.