The non-mevalonate isoprenoid biosynthesis of plants as a test system for drugs against malaria and pathogenic bacteria. (December 2000)

• Record Type: Journal Article
• Authors: Zeidler, J.; Schwender, J.; Mueller, C.; Lichtenthaler, H. K.
• Is Part Of: Biochemical Society transactions. Volume 28:Number 6(2000)
• Page Start: 796
• Page End: 798
• Publication Date: 2000-12
• Subjects: antibiotic -- drug target -- herbicide -- isoprene; DOXP, deoxyxylulose 5-phosphate -- DXR, DOXP reductoisomerase -- DXS, DOXP synthase -- MEP, methylerythritol 4-phosphate -- 1PP, isopentenyl diphosphate; Biochemistry -- Congresses; 572
• DOI: 10.1042/bst0280796
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Two plant test systems are presented in the search for new inhibitors of the non-mevalonate isoprenoid pathway. A derivative of clomazone appears to be an inhibitor of the deoxyxylulose 5-phosphate/methylerythritol 4-phosphate (DOXP/MEP) pathway of isoprenoid formation.