A brief history of TOR. (22nd March 2011)
- Record Type:
- Journal Article
- Title:
- A brief history of TOR. (22nd March 2011)
- Main Title:
- A brief history of TOR
- Authors:
- Loewith, Robbie
- Abstract:
- Abstract : The TOR (target of rapamycin) serine/threonine kinases are fascinating in that they influence many different aspects of eukaryote physiology including processes often dysregulated in disease. Beginning with the initial characterization of rapamycin as an antifungal agent, studies with yeast have contributed greatly to our understanding of the molecular pathways in which TORs operate. Recently, building on advances in quantitative MS, the rapamycin-dependent phosphoproteome in the budding yeast Saccharomyces cerevisiae was elucidated. These studies emphasize the central importance of TOR and highlight its many previously unrecognized functions. One of these, the regulation of intermediary metabolism, is discussed.
- Is Part Of:
- Biochemical Society transactions. Volume 39:Number 2(2011)
- Journal:
- Biochemical Society transactions
- Issue:
- Volume 39:Number 2(2011)
- Issue Display:
- Volume 39, Issue 2 (2011)
- Year:
- 2011
- Volume:
- 39
- Issue:
- 2
- Issue Sort Value:
- 2011-0039-0002-0000
- Page Start:
- 437
- Page End:
- 442
- Publication Date:
- 2011-03-22
- Subjects:
- antifungal agent -- intermediary metabolism -- rapamycin -- target of rapamycin (TOR) -- target of rapamycin complex (TORC) -- yeast
Biochemistry -- Congresses
572 - Journal URLs:
- https://portlandpress.com/biochemsoctrans ↗
- DOI:
- 10.1042/BST0390437 ↗
- Languages:
- English
- ISSNs:
- 0300-5127
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD Digital store
- Ingest File:
- 16144.xml