Mood in Parkinson's disease: From early‐ to late‐stage disease. (20th November 2020)

• Record Type: Journal Article
• Authors: Santos‐García, Diego; De Deus, Fonticoba T.; Cores, Bartolome C.; Valdés, Aymerich L.; Suárez, Castro E.; Aneiros, Ángel; Jesús, Silvia; Aguilar, Miquel; Pastor, Pau; Planellas, Lluís; Cosgaya, Marina; García, Caldente J.; Caballol, Nuria; Legarda, Inés; Hernández, Vara J.; Cabo, Iria; López, Manzanares L.; González, Aramburu I.; Ávila, Rivera M. A.; José, Catalán M.; Nogueira, Víctor; Puente, Víctor; García, Moreno J. M.; Borrué, Carmen; Solano, Vila B.; Álvarez, Sauco M.; Vela, Lydia; Escalante, Sonia; Cubo, Esther; Carrillo, Padilla F.; Martínez, Castrillo J. C.; Sánchez, Alonso P.; Alonso, Losada M. G.; López, Ariztegui N.; Gastón, Itziar; Kulisevsky, Jaime; Blázquez, Estrada M.; Seijo, Manuel; Rúiz, Martínez J.; Valero, Caridad; Kurtis, Mónica; de Fábregues‐Boixar, Oriol; González, Ardura J.; Prieto, Jurczynska C.; López, Díaz L.; McAfee, Darrian; Mir, Pablo;
• Is Part Of: International journal of geriatric psychiatry. Volume 36:Number 5(2021)
• Page Start: 627
• Page End: 646
• Publication Date: 2020-11-20
• Subjects: depression -- disease duration -- mood -- Parkinson's disease -- quality of life; Geriatric psychiatry -- Periodicals; Geriatric Psychiatry -- Periodicals; 618.97689
• DOI: 10.1002/gps.5461
• Languages: English
• ISSNs: 0885-6230

Abstract

Abstract: Background: Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration. Methods: PD patients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross‐sectional study. Three groups were defined: <5 years (Group A); from 5 to <10 years (Group B); ≥10 years (Group C). Analysis with well‐planned linear regression models was conducted to determine how different factors contribute to mood (Beck Depression Inventory‐II [BDI‐II] as dependent variable), to health‐related QoL (39‐item Parkinson's Disease Questionnaire [PDQ‐39SI] as dependent variable) and to global QoL (European Health Interview Survey – Quality of Life Eight‐Item Index [EUROHIS‐QOL8] as dependent variable). Results: Six hundred and sixty‐three PD patients (62.6 ± 8.9 years old, 59.6% males) were included: Group A, 50.1% ( n = 332); Group B, 33.3% ( n = 221) and Group C, 16.6% ( n = 110). There were no differences between the three groups in terms of the frequency of depressive symptoms nor the frequency of depression type (major vs. minor vs. subthreshold) ( p = 0.729). However, the unique percent variance of PDQ‐39SI and EUROHIS‐QOL8 explained by BDI‐II total score was 2 (23.7%) and threefold (26.9%), respectively, in Group C compared to the other two groups. EUROHIS‐QOL8 total score provided the highest unique contribution to mood (16.8%). Conclusions: Although depression‐type frequency does not appear to change over time in PD; the contribution of mood on QoL perception is greater in patients with longer disease duration.