The mechanism of inhibition of ureogenesis by acidosis. Issue 10 (October 1984)

• Record Type: Journal Article
• Authors: Monson, J. P.; Henderson, R. M.; Smith, J. A.; Iles, R. A.; Faus-Dader, M.; Carter, N. D.; Heath, R.; Metcalfe, H.; Cohen, R. D.
• Is Part Of: Bioscience reports. Volume 4:Issue 10(1984)
• Page Start: 819
• Page End: 825
• Publication Date: 1984-10
• Subjects: Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01138163
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : In perfused rat liver a decrease of cytosol pH, determined with pH-sensitive microelectrodes7 from 7.2 to 6.85 is associated with a 50% fall in ureogenesis from ammonium chloride. In isolated rat hepatocytes the fall in ureogenesis due to acidosis is associated with decrease in the mitochondrial and cytosolic concentration of citrulline. Limitation of carbamoyl phosphate synthesis and thus citrulline supply could be responsible for the inhibition of ureogenesis observed.