Evolving techniques for the investigation of muscle bioenergetics and oxygenation. (April 2002)

• Record Type: Journal Article
• Authors: Richardson, R. S.; Noyszewski, E. A.; Haseler, L. J.; Bluml, S.; Frank, L. R.
• Is Part Of: Biochemical Society transactions. Volume 30:Number 2(2002)
• Page Start: 232
• Page End: 237
• Publication Date: 2002-04
• Subjects: ASL, arterial spin labelling -- CSI, chemical shift imaging -- Mb, myoglobin -- MRI, magnetic resonance imaging -- MRS, magnetic resonance spectroscopy -- PCr, phosphocreatine -- Po2, partial pressure of oxygen -- , blood flow -- RF, radio frequency -- o2, oxygen uptake; arterial spin labelling -- chemical shift imaging -- exercise -- myoglobin -- perfusion; Biochemistry -- Congresses; 572
• DOI: 10.1042/bst0300232
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are both powerful, non-invasive methodologies and, as such, offer great potential to investigate both human biochemistry and human physiology, and ultimately to contribute significantly to the field of medicine. Consequently there has been much effort devoted to fostering the evolution of these methodologies into distinct and applicable techniques. Here we will highlight several MRI and MRS techniques for the assessment of human biochemistry and physiology that ultimately may provide useful clinical assessments and diagnoses of various muscular and cardiovascular pathologies. Specifically, the evolving techniques that will be discussed are: (1) 1 H MRS of myoglobin to assess the intracellular partial pressure of O2, (2) 31 P MRS to assess metabolic capacity, and (3) the combination of 31 P chemical shift imaging to assess local metabolic demand (oxygen uptake; o2 ) with arterial spin labelling to assess local perfusion (blood flow; ), in an effort to characterize the elusive spatial matching of skeletal muscle ( / o2 ).