Defluorinative phosphorylation of perfluoroalkyl ketones: synthesis of fluoroalkylated and phosphorylated furan derivatives. Issue 7 (4th February 2021)

• Record Type: Journal Article
• Authors: Wang, Qing-Dong; Zhang, Chen; Sun, Li-Wen; Luo, Xin-Long; Rao, Weidong; Shen, Zhi-Liang; Chu, Xue-Qiang
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 7(2021)
• Page Start: 1503
• Page End: 1509
• Publication Date: 2021-02-04
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo01631d
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An efficient method for the synthesis of fluoroalkylated tri(hetero)arylphosphine oxides from polyfluoroalkyl ketones and phosphine oxides or phosphonates has been developed. Abstract : Efficient synthesis of fluoroalkylated tri(hetero)arylphosphine oxides from perfluoroalkyl ketones and phosphine oxides or phosphonates has been achieved via successive C(sp 3 )–F bond activation under mild reaction conditions. This approach involving new C(sp 2 )–P/C(sp 2 )–O bond formation and fluoroalkylated heterocycle construction distinguishes itself by its broad substrate scope and synthetic simplicity. Moreover, tri(hetero)arylphosphines could also be prepared in high yields by further reductive transformation.