Corticotropin-releasing hormone receptors. (August 2002)

• Record Type: Journal Article
• Authors: Hillhouse, E. W.; Randeva, H.; Ladds, G.; Grammatopoulos, D.
• Is Part Of: Biochemical Society transactions. Volume 30:Number 4(2002)
• Page Start: 428
• Page End: 432
• Publication Date: 2002-08
• Subjects: CRH -- G-protein-coupled receptors -- receptor isoforms -- urocortin; CRH, corticotropin-releasing hormone -- CRH-RI (2), CRP receptor type 1(2) -- GPCR, G-protein-coupled receptor -- HEK, human embryonic kidney -- MAPK, mitogenactivated protein kinase -- PKC, protein kinase C -- SCP, stresscopin -- SRP, stresscopin-related peptide; Biochemistry -- Congresses; 572
• DOI: 10.1042/bst0300428
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural and functional characteristics of the family of CRH-like peptides and their receptors.