A facile and practical preparation of P-chiral phosphine oxides. Issue 27 (5th March 2021)

• Record Type: Journal Article
• Authors: Xu, Ronghua; Gao, Zhenhua; Yu, Yiteng; Tang, Yehua; Tian, Duanshuai; Chen, Tian; Chen, Yibing; Xu, Guangqing; Shi, Enxue; Tang, Wenjun
• Is Part Of: Chemical communications. Volume 57:Issue 27(2021)
• Page Start: 3335
• Page End: 3338
• Publication Date: 2021-03-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc00646k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A practical and cost-effective synthetic method of P -chiral diarylalkyl, aryldialkyl, and triaryl phosphine oxides by using readily available chiral diphenyl-2-pyrrolidinemethanol as the auxiliary is developed. The long-standing racemization issue during solvolysis has been addressed. Abstract : A practical and cost-effective synthetic method of P -chiral diarylalkyl, aryldialkyl, and triaryl phosphine oxides by using readily available chiral diphenyl-2-pyrrolidinemethanol as the auxiliary is developed. The long-standing racemization issue during solvolysis has been addressed and well controlled by employing a suitable solvent, a low reaction temperature, and an appropriate reaction time.