Biphasic nucleophilic aromatic substitution using a microreactor under droplet formation conditions. Issue 4 (26th February 2021)

• Record Type: Journal Article
• Authors: Mori, Hajime; Nishiyama, Yasuhiro; Fujii, Akira; Saito, Akane; Torikai, Hitoshi; Hanasaka, Toshiaki; Koishi, Hideyuki
• Is Part Of: Reaction chemistry & engineering. Volume 6:Issue 4(2021)
• Page Start: 720
• Page End: 725
• Publication Date: 2021-02-26
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/d1re00014d
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : Biphasic nucleophilic aromatic substitution of 4-fluoronitrobenzene proceeded efficiently using a packed bed reactor. Abstract : The biphasic nucleophilic aromatic substitution of 4-fluoronitrobenzene was carried out using a microreactor. To realize an efficient reaction process, we performed microflow reactions under droplet formation conditions to give the substituted products in excellent yields. The solvent effect was also investigated, and it was found that the use of diisobutyl ketone as an organic phase greatly accelerated the reaction.