Laminin-111 Improves the Anabolic Response to Mechanical Load in Aged Skeletal Muscle. (7th December 2020)

• Record Type: Journal Article
• Authors: Garg, Koyal; Mahmassani, Ziad S; Dvoretskiy, Svyatoslav; Valero, M Carmen; Huntsman, Heather D; Lapp, Samuel; Wu, Yu-Fu; Hauschka, Stephen D; Burkin, Dean J; Boppart, Marni D
• Editors: Anderson, Rozalyn M
• Is Part Of: Journals of gerontology. Volume 76:Number 4(2021)
• Page Start: 586
• Page End: 590
• Publication Date: 2020-12-07
• Subjects: Aging -- Chronic mechanical loading -- Extracellular matrix -- Hypertrophy -- Integrin; Geriatrics -- Periodicals; Gerontology -- Periodicals; 618.97
• DOI: 10.1093/gerona/glaa308
• Languages: English
• ISSNs: 1079-5006

Abstract

Abstract: Anabolic resistance to a mechanical stimulus may contribute to the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected with saline or human LM-111 (1 mg/kg). One week later, the myotendinous junction of the gastrocnemius muscle was removed via myotenectomy (MTE), thus placing a chronic mechanical stimulus on the remaining plantaris muscle for 2 weeks. LM-111 increased α7B integrin protein expression and clustering of the α7B integrin near DAPI + nuclei in aged muscle in response to MTE. LM-111 reduced CD11b + immune cells, enhanced repair, and improved the growth response to loading in aged plantaris muscle. These results suggest that LM-111 may represent a novel therapeutic approach to prevent and/or treat sarcopenia.