Analysis of urinary microRNAs in chronic kidney disease. (20th July 2012)

• Record Type: Journal Article
• Authors: Beltrami, Cristina; Clayton, Aled; Phillips, Aled O.; Fraser, Donald J.; Bowen, Timothy
• Is Part Of: Biochemical Society transactions. Volume 40:Number 4(2012)
• Page Start: 875
• Page End: 879
• Publication Date: 2012-07-20
• Subjects: biomarker -- chronic kidney disease (CKD) -- exosome -- microRNA (miRNA) -- urine; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20120090
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Kidney biopsy is the gold-standard diagnostic test for intrinsic renal disease, but requires hospital admission and carries a 3% risk of major complications. Current non-invasive prognostic indicators such as urine protein quantification have limited predictive value. Better diagnostic and prognostic tests for chronic kidney disease patients are a major focus for industry and academia, with efforts to date directed largely at urinary proteomic approaches. microRNAs constitute a recently identified class of endogenous short non-coding single-stranded RNA oligonucleotides that regulate gene expression post-transcriptionally. Quantification of urinary microRNAs offers an alternative approach to the identification of chronic kidney disease biomarkers.