Interactions between G-protein-coupled receptors and periplakin: a selective means to regulate G-protein activation. (26th October 2004)

• Record Type: Journal Article
• Authors: Milligan, G.; Murdoch, H.; Kellett, E.; White, J.H.; Feng, G.-J.
• Is Part Of: Biochemical Society transactions. Volume 32:Number 5(2004)
• Page Start: 878
• Page End: 880
• Publication Date: 2004-10-26
• Subjects: cytoskeleton -- G-protein -- G-protein-coupled receptor -- melanin concentrating hormone -- opioid -- plakin; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0320878
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : A substantial number of G-protein-coupled receptor-interacting proteins have been identified initially by the use of yeast two-hybrid screens. Using the C-terminal tail of both opioid receptors and the melanin concentrating hormone receptor-1 as bait, the actin and intermediate filament-binding protein periplakin was isolated. In each case, the site of interaction is within helix VIII of the receptor and periplakin limits agonist-mediated G-protein activation potentially by competing with G-protein for this region of the receptor.