The control of blood platelets by cAMP signalling. (20th March 2014)

• Record Type: Journal Article
• Authors: Raslan, Zaher; Naseem, Khalid M.
• Is Part Of: Biochemical Society transactions. Volume 42:Number 2(2014)
• Page Start: 289
• Page End: 294
• Publication Date: 2014-03-20
• Subjects: A-kinase-anchoring protein (AKAP) -- cAMP -- compartmentalization -- phosphodiesterase (PDE) -- platelet -- protein kinase A (PKA); Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20130278
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Blood platelet activation must be tightly regulated to ensure a balance between haemostasis and thrombosis. The cAMP signalling pathway is the most powerful endogenous regulator of blood platelet activation. PKA (protein kinase A), the foremost effector of cAMP signalling in platelets, phosphorylates a number of proteins that are thought to modulate multiple aspects of platelet activation. In the present mini-review, we outline our current understanding of cAMP-mediated platelet inhibition and discuss some of the issues that require clarification.