[NiFe]-Hydrogenase maturation endopeptidase: structure and function. (1st February 2005)

• Record Type: Journal Article
• Authors: Theodoratou, E.; Huber, R.; Böck, A.
• Is Part Of: Biochemical Society transactions. Volume 33:Number 1(2005)
• Page Start: 108
• Page End: 111
• Publication Date: 2005-02-01
• Subjects: cleavage site -- endopeptidase mutants -- hydrogenase -- metal centre -- substrate complex; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0330108
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Hydrogenase maturation endopeptidases catalyse the terminal step in the maturation of the large subunit of [NiFe]-hydrogenases. They remove a C-terminal extension from the precursor of the subunit, triggering a conformational switch that results in the bridging of the Fe and Ni atoms of the metal centre via the thiolate of a cysteine residue and in closure of the centre. This review summarizes what is known about the structure of the protein, its substrate specificity and its possible reaction mechanism.