14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin. (August 2002)

• Record Type: Journal Article
• Authors: Klein, D. C.; Ganguly, S.; Coon, S.; Weller, J. L.; Obsil, T.; Hickman, A.; Dyda, F.
• Is Part Of: Biochemical Society transactions. Volume 30:Number 4(2002)
• Page Start: 365
• Page End: 373
• Publication Date: 2002-08
• Subjects: cAMP-dependent protein kinase -- N-acetyltransferase, pineal; AANAT, arylalkylamine N-acetyltransferase -- PKA, cAMP-dependent protein kinase; Biochemistry -- Congresses; 572
• DOI: 10.1042/bst0300365
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : This paper describes the role 14-3-3 proteins play in vertebrate photoneuroendocrine transduction. 14-3-3 proteins form a complex with arylalkylamine N-acetyltransferase (AANAT), the enzyme which turns melatonin production on during the day and off at night. Complex formation is triggered at night by cAMP-dependent phosphorylation of the enzyme, and results in activation and protection against proteolysis. This enhances melatonin production > 10-fold. Light exposure results in dephosphorylation of the enzyme and disassociation from 14-3-3, leading to destruction and a rapid drop in melatonin production and release and circulating levels.