Histone variants and lipid metabolism. (18th September 2014)

• Record Type: Journal Article
• Authors: Borghesan, Michela; Mazzoccoli, Gianluigi; Sheedfar, Fareeba; Oben, Jude; Pazienza, Valerio; Vinciguerra, Manlio
• Is Part Of: Biochemical Society transactions. Volume 42:Number 5(2014)
• Page Start: 1409
• Page End: 1413
• Publication Date: 2014-09-18
• Subjects: gene expression -- histone variant -- lipid metabolism -- nucleosome -- steatosis; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20140119
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.