Bone marrow contribution to the heart from development to adulthood. (April 2021)

• Record Type: Journal Article
• Authors: Sampaio-Pinto, Vasco; Ruiz-Villalba, Adrián; Nascimento, Diana S.; Pérez-Pomares, José M.
• Is Part Of: Seminars in cell & developmental biology. Volume 112(2021)
• Page Start: 16
• Page End: 26
• Publication Date: 2021-04
• Subjects: Fetal and adult hematopoiesis -- Blood lineages -- Heart tissue homeostasis -- Cardiac disease; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2020.06.008
• Languages: English
• ISSNs: 1084-9521

Abstract

Highlights: Bone marrow-derived cells are essential components of fetal and adult cardiac tissues. Yolk sac-derived primitive blood cells (mostly macrophages) are the first blood lineages recruited to the forming heart. Bone marrow is the principal adult source of cardiac resident blood cells. Heart homeostasis and cardiac response to pathologic stimuli strongly rely on blood-lineage cells. Abstract: Cardiac chamber walls contain large numbers of non-contractile interstitial cells, including fibroblasts, endothelial cells, pericytes and significant populations of blood lineage-derived cells. Blood cells first colonize heart tissues a few days before birth, although their recruitment from the bloodstream to the cardiac interstitium is continuous and extends throughout adult life. The bone marrow, as the major hematopoietic site of adult individuals, is in charge of renewing all circulating cell types, and it therefore plays a pivotal role in the incorporation of blood cells to the heart. Bone marrow-derived cells are instrumental to tissue homeostasis in the steady-state heart, and are major effectors in cardiac disease progression. This review will provide a comprehensive approach to bone marrow-derived blood cell functions in the heart, and discuss aspects related to hot topics in the cardiovascular field like cell-based heart regeneration strategies.