Microfluidic-based models to address the bone marrow metastatic niche complexity. (April 2021)

• Record Type: Journal Article
• Authors: Ribeiro, Patrícia; Leitão, Luís; Monteiro, Ana C.; Bortolin, Andrea; Moura, Beatriz; Lamghari, Meriem; Neto, Estrela
• Is Part Of: Seminars in cell & developmental biology. Volume 112(2021)
• Page Start: 27
• Page End: 36
• Publication Date: 2021-04
• Subjects: 3D three-dimensional -- ALL acute lymphoblastic leukemia -- BC breast cancer -- BM bone marrow -- BMSCs bone marrow stromal cells -- CTCs circulating tumor cells -- CXCL12 C-X-C motif chemokine ligand 12 -- CXCR4 C-X-C chemokine receptor type 4 -- ECM extracellular matrix -- EMT epithelial–mesenchymal transition HSCs, hematopoietic stem cells -- HPSCs hematopoietic stem and progenitor cells -- HUVECs human umbilical vein endothelial cells -- ICAM intercellular adhesion molecule 1 -- IGF insulin-like growth factor -- IL-6 interleukin 6 -- MM multiple myeloma -- MSCs mesenchymal stem cells -- PDGF platelet-derived growth factor -- PDMS poly(dimethylsiloxane) -- Ph+ philadelphia chromosome positive -- TIMP-1 tissue inhibitor matrix metalloproteinase 1 -- VCAM-1 vascular cell adhesion molecule 1 -- VE vascular endothelial -- VEGF vascular endothelial growth factor -- ZO-1 zonula occludens-1; Microfluidic -- Bone marrow -- Bone-on-a-chip -- Metastases -- Therapies; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2020.05.015
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Bone marrow (BM) is a preferential metastatic site for solid cancers, contributing to higher morbidity and mortality among millions of oncologic patients worldwide. There are no current efficient therapies to minimize this health burden. Microfluidic based in vitro models emerge as powerful alternatives to animal testing, as well as promising tools for the development of personalized medicine solutions. The complexity associated with the BM metastatic niche originated a wide variety of microfluidic platforms designed to mimic this microenvironment. This review gathers the essential parameters to design an accurate in vitro microfluidic device, based on a comparative analysis of existing models created to address the different steps of the metastatic cascade.