A role of SAND-family proteins in endocytosis. (1st August 2005)

• Record Type: Journal Article
• Authors: Poteryaev, D.; Spang, A.
• Is Part Of: Biochemical Society transactions. Volume 33:Number 4(2005)
• Page Start: 606
• Page End: 608
• Publication Date: 2005-08-01
• Subjects: Caenorhabditis elegans -- endocytosis -- Rab7 -- receptor-mediated endocytosis defective (rme) screen -- SAND family -- vacuole; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0330606
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Caenorhabditis elegans has recently been used as an attractive model system to gain insight into mechanisms of endocytosis in multicellular organisms. A combination of forward and reverse genetics has identified a number of new membrane trafficking factors. Most of them have mammalian homologues which function in the same transport events. We describe a novel C. elegans gene sand-1, whose loss of function causes profound endocytic defects in many tissues. SAND-1 belongs to a conserved family of proteins present in all eukaryotic species, whose genome is sequenced. However, SAND family has not been previously characterized in metazoa. Our comparison of C. elegans SAND-1 and its yeast homologue, Mon1p, showed a conserved role of the SAND-family proteins in late steps of endocytic transport.