Regulation of gene expression by the RNA-binding protein Sam68 in cancer. (21st May 2008)

• Record Type: Journal Article
• Authors: Rajan, Prabhakar; Gaughan, Luke; Dalgliesh, Caroline; El-Sherif, Amira; Robson, Craig N.; Leung, Hing Y.; Elliott, David J.
• Is Part Of: Biochemical Society transactions. Volume 36:Number 3(2008)
• Page Start: 505
• Page End: 507
• Publication Date: 2008-05-21
• Subjects: cancer -- cell cycle -- RNA processing -- signal transducer and activator of RNA (STAR) -- Src-associated in mitosis 68 kDa (Sam68) -- transcription; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0360505
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.