Solid subtype predicts early bone metastases in sensitive EGFR-mutated lung adenocarcinoma patients after surgery. (April 2021)

• Record Type: Journal Article
• Authors: Xiong, Anning; Li, Changhui; Xu, Jianlin; Yang, Xiaohua; Nie, Wei; Zhong, Hua; Chu, Tianqing; Zhang, Wei; Zhong, Runbo; Pan, Feng; Shen, Yinchen; Lou, Yuqing; Zhang, Bo; Han, Baohui; Zhang, Xueyan
• Is Part Of: Lung cancer. Volume 154(2021)
• Page Start: 124
• Page End: 130
• Publication Date: 2021-04
• Subjects: NSCLC Non-small cell lung cancer -- BM bone metastases -- EGFR epidermal growth factor receptor -- SREs skeletal related events -- IASLC International Association for the Study of Lung Cancer -- ATS American Thoracic Society -- ERS European Respiratory Society -- TKI tyrosine kinase inhibitor -- ARMS amplification system technology -- DFS disease-free survival -- bDFS bone disease-free survival -- OS overall survival -- HR hazard ratio -- CIs confidence intervals -- EPCs endothelial progenitor cells -- TTF-1 thyroid transcription factor-1; Histologic subtype -- Distant metastasis -- Non-Small cell lung cancer; Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2021.02.029
• Languages: English
• ISSNs: 0169-5002

Abstract

Highlights: Solid component is a predictive factor of promoted disease progression. Solid pattern is associated with poor overall survival. Lung adenocarcinoma patients with solid pattern develop bone metastases earlier. Abstract: This study aimed to explore the prognostic significance of solid pattern for bone metastases (BM) in epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma patients after surgery. A total of 237 stage I-III lung adenocarcinoma patients with EGFR mutation were analyzed after procedure. The patients were divided into four groups: the solid-present patients with BM, the solid-absent patients with BM, the solid-present patients without BM and the solid-absent patients without BM. The bone disease-free survival (bDFS), systemic disease-free survival (DFS) and overall survival (OS) were assessed. The results revealed that the patients with solid pattern had shorter DFS (15 months vs. 19 months; P < 0.001) and OS (47 months vs. 77 months; P = 0.001). Moreover, bDFS of solid-present patients was significantly shorter than solid-absent patients (27 months vs. 14 months; P < 0.001). In addition, patients with solid component had worsened bDFS, no matter with BM as first-site development (12.5 months vs. 16.5 months; P = 0.016) or non-first-site development (16.5 months vs. 45.5 months; P < 0.001). These findings suggested that solid pattern predicted worse DFS and OS and also showed shortened interval between surgery and BM.