Is a third proton-conducting pathway operative in bacterial cytochrome c oxidase?. (1st August 2005)

• Record Type: Journal Article
• Authors: Salje, J.; Ludwig, B.; Richter, O.-M.H.
• Is Part Of: Biochemical Society transactions. Volume 33:Number 4(2005)
• Page Start: 829
• Page End: 831
• Publication Date: 2005-08-01
• Subjects: bacterial oxidase -- cytochrome c -- haem a -- H-channel -- Paracoccus denitrificans -- proton-conducting pathway; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0330829
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Despite the existence of several three-dimensional structures of cytochrome c oxidases, a detailed understanding of pathways involved in proton movements through the complex remains largely elusive. Next to the two well-established pathways (termed D and K), an additional proton-conducting network ('H-channel') has been proposed for the beef heart enzyme. Yet, our recent mutational studies on corresponding residues of the Paracoccus denitrificans cytochrome c oxidase provide no clues that such a pathway operates in the prokaryotic enzyme.