Peptide T from human immunodeficiency virus does not interact with VIP receptor-effector system in immunocompetent cells of rat and mouse. Issue 5 (October 1994)

• Record Type: Journal Article
• Authors: Pozo, D.; Segura, J. J.; Guerrero, J. M.; Calvo, J. R.
• Is Part Of: Bioscience reports. Volume 14:Issue 5(1994)
• Page Start: 251
• Page End: 257
• Publication Date: 1994-10
• Subjects: VIP -- immunocompetent cells -- HIV -- peptide T; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01209730
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Human immunodeficiency virus (HIV) infection is initiated by attachment of the virus to specific target cells. An octapeptide sequence contained within the envelope of HIV, peptide T, mediates the viral binding. Since there is an appreciable structural similarity between peptide T and an eight amino acid sequence of VIP, it is interesting to investigate the interaction of peptide T with the VIP receptor-effector system of immunocompetent cells from both rat and mouse. In this paper, we show the lack of interaction between peptide T and VIP receptor-effector system in peripheral blood lymphocytes, spleen lymphocytes and macrophages of rat and in macrophages of mouse. These results do not support the hypothesis that HIV through peptide T may interact with the VIP receptor-effector system present in immunocompetent cells.