Platelets immune response against Mycobacterium tuberculosis infection. (April 2021)

• Record Type: Journal Article
• Authors: Torres-Juarez, Flor; Trejo-Martínez, Luis A.; Layseca-Espinosa, Esther; Leon-Contreras, Juan C.; Enciso-Moreno, Jose A.; Hernandez-Pando, Rogelio; Rivas-Santiago, Bruno
• Is Part Of: Microbial pathogenesis. Volume 153(2021)
• Publication Date: 2021-04
• Subjects: Tuberculosis -- Platelets -- Immune response -- Host defense peptides; platelets (PLT) activated platelets (A-PLT) -- Mycobacterium tuberculosis (Mtb) tuberculosis (TB) -- Host Defense Peptides (HDPs) human β-defensin 2 (HBD2) and human-platelet factor 4 (hPF-4); Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2021.104768
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Tuberculosis (TB) is the first cause of death by a single infectious agent. Previous reports have highlighted the presence of platelets within Tb granulomas, albeit the immune-associated platelet response to Mycobacterium tuberculosis (Mtb) has not been deeply studied. Our results showed that platelets are recruited into the granuloma in the late stages of tuberculosis. Furthermore, electron-microscopy studies showed that platelets can internalize Mtb and produce host defense peptides (HDPs), such as RNase 7, HBD2 and hPF-4 that bind to the internalized Mtb. Mtb-infected platelets exhibited higher transcription and secretion of IL-1β and TNF-α, whereas IL-10 and IL-6 protein levels decreased. These results suggest that platelets participate in the immune response against Mtb through HDPs and cytokines production. Highlights: Platelets are involved in the immune response versus M. tuberculosis . Platelets engulf Mycobacterium tuberculosis, independently of their activation stage. Platelets have antimicrobial peptides into their cytoplasm, which interact with internalized Mtb. Mycobacterium tuberculosis modulate the cytokine profile produced by platelets.