The effect of different hyperglucagonemic states on monooxygenase activities and isozymic pattern of cytochrome P-450 in mouse. Issue 4 (April 1985)

• Record Type: Journal Article
• Authors: Rouer, E.; Beaune, P.; Augereau, C.; Leroux, J. P.
• Is Part Of: Bioscience reports. Volume 5:Issue 4(1985)
• Page Start: 335
• Page End: 341
• Publication Date: 1985-04
• Subjects: Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01116906
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : The continuous infusion of a low dose of glucagon (35 μg/kg/d, for 5 d) constitutes, in view of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities, a reliable experimental model of hyperglucagonemia. By conjunction of monooxygenase assays and immunoquantitation of specific isozymes of cytochrome P-450, the actual inducing ability of glucagon has been shown and it might explain some of the modifications of the drug metabolizing system in diabetic mice. The isozymic pattern of cytochrome P-430 of liver microsomes from diabetic mice appears very different from that produced by classical inducers.