Sex differences in US emergency department non-fatal visits for benzodiazepine poisonings in adolescents and young adults. (1st April 2021)

• Record Type: Journal Article
• Authors: Bushnell, Greta A.; Olfson, Mark; Martins, Silvia S.
• Is Part Of: Drug and alcohol dependence. Volume 221(2021)
• Publication Date: 2021-04-01
• Subjects: Benzodiazepine -- Poisoning -- Emergency department -- Sex -- Adolescents; Drug abuse -- Periodicals; Alcoholism -- Periodicals; 616.86
• DOI: 10.1016/j.drugalcdep.2021.108609
• Languages: English
• ISSNs: 0376-8716

Abstract

Highlights: To help reduce drug mortality, attention should be paid to BZD-related overdoses. Half of BZD poisonings in young (12–29) females and a third in males were intentional. Most BZD poisonings involved mental health or substance use disorder diagnoses. BZD poisonings in youth commonly involved another substance (33–53 %). Sex differences in BZD poisonings occur by intent, concurrent substances, and diagnoses. Abstract: Background: Benzodiazepine (BZD)-related overdose deaths have risen in the past decade and BZD misuse contributes to thousands of emergency department (ED) visits annually, with the highest rates in adolescents and young adults. Because there are gaps in understanding BZD poisoning in youth and whether differences occur by sex, we aimed to characterize BZD poisoning ED visits in young people by sex. Methods: BZD poisoning visits were identified in the Nationwide Emergency Department Sample, among adolescents (12−17 years) and young adults (18−29 years). Stratified by sex and age, we described ED visits for BZD poisonings in 2016, including poisoning intent, concurrent substances involved, and co-occurring mental health disorder diagnoses. With logistic regression we examined the association between intent and concurrent substance. Results: There were approximately 38, 000 BZD poisoning ED visits by young people nationwide with annual population rates per 10, 000 of 2.9=adolescents and 5.8=young adults. Depression was diagnosed in 40 % of female and 23 % of male BZD visits (p < 0.01). Over half of BZD poisonings in females and a third in males were intentional (p < 0.01). Male BZD visits were more likely to involve opioids or cannabis and less likely to involve antidepressants than females (p-values<0.01). In males and females, BZD poisonings concurrent with antidepressants and other psychotropic medications were more likely to be intentional than unintentional (OR range:2.1–6.3). Conclusions: The high proportion of BZD poisonings that are intentional and include mental health disorder diagnoses, especially among young females, underscore the importance of ED mental health and suicide risk assessment with appropriate follow-up referral.