Similarities between ATP-dependent and ion-coupled multidrug transporters. (26th October 2005)

• Record Type: Journal Article
• Authors: Venter, H.; Shahi, S.; Balakrishnan, L.; Velamakanni, S.; Bapna, A.; Woebking, B.; van Veen, H.W.
• Is Part Of: Biochemical Society transactions. Volume 33:Number 5(2005)
• Page Start: 1008
• Page End: 1011
• Publication Date: 2005-10-26
• Subjects: ATP-binding cassette transporter (ABC transporter) -- carboxylate -- LmrA -- multidrug resistance -- secondary-active transporter -- transmembrane segment (TMS); Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0331008
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The movement of drugs across biological membranes is mediated by two major classes of membrane transporters. Primary-active, ABC (ATP-binding cassette) multidrug transporters are dependent on ATP-binding/hydrolysis, whereas secondary-active multidrug transporters are coupled to the proton (or sodium)-motive force that exists across the plasma membrane. Recent work on LmrA, an ABC multidrug transporter in Lactococcus lactis, suggests that primary- and secondary-active multidrug transporters share functional and structural features. Some of these similarities and their implications for the mechanism of transport by ABC multidrug transporters will be discussed.