Source imaging of deep-brain activity using the regional spatiotemporal Kalman filter. (March 2021)

• Record Type: Journal Article
• Authors: Hamid, Laith; Habboush, Nawar; Stern, Philipp; Japaridze, Natia; Aydin, Ümit; Wolters, Carsten H.; Claussen, Jens Christian; Heute, Ulrich; Stephani, Ulrich; Galka, Andreas; Siniatchkin, Michael
• Is Part Of: Computer methods and programs in biomedicine. Volume 200(2021)
• Publication Date: 2021-03
• Subjects: Deep sources -- Dynamical inverse solution -- EEG -- EEG inverse problem -- EEG source imaging -- Electroencephalography -- Epilepsy -- Epileptiform activity -- Kalman filter -- LORETA -- RSTKF -- Source reconstruction -- Spatiotemporal Kalman filter -- State space -- STKF -- Subcortical sources; Medicine -- Computer programs -- Periodicals; Biology -- Computer programs -- Periodicals; Computers -- Periodicals; Medicine -- Periodicals; Médecine -- Logiciels -- Périodiques; Biologie -- Logiciels -- Périodiques; Biology -- Computer programs; Medicine -- Computer programs; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.cmpb.2020.105830
• Languages: English
• ISSNs: 0169-2607

Abstract

Highlights: A novel electroencephalographic (EEG) source imaging method, the regional spatiotemporal Kalman filter (RSTKF), which allows characterization of different regional dynamics in the brain is presented. Simulated subcortical sources from the putamen and thalamus as well as an epileptic generator in the amygdalo-hippocampal complex are used to test the method. Only RSTKF is successful in consistently and accurately localizing the sources in deep brain regions. Additionally, RSTKF shows improved spatial resolution compared to LORETA and STKF. In contrast to standard source imaging methods, RSTKF may find application in the localization of the epileptogenic zone in deeper brain structures, such as mesial frontal and temporal lobe epilepsies. The new method has shown promising results in the case of deep brain sources from EEG recordings with fewer than 64 electrodes, and without the need for averaged spikes. Abstract: Background and objective: The human brain displays rich and complex patterns of interaction within and among brain networks that involve both cortical and subcortical brain regions. Due to the limited spatial resolution of surface electroencephalography (EEG), EEG source imaging is used to reconstruct brain sources and investigate their spatial and temporal dynamics. The majority of EEG source imaging methods fail to detect activity from subcortical brain structures. The reconstruction of subcortical sources is a challenging task because the signal from these sources is weakened and mixed with artifacts and other signals from cortical sources. In this proof-of-principle study we present a novel EEG source imaging method, the regional spatiotemporal Kalman filter (RSTKF), that can detect deep brain activity. Methods: The regional spatiotemporal Kalman filter (RSTKF) is a generalization of the spatiotemporal Kalman filter (STKF), which allows for the characterization of different regional dynamics in the brain. It is based on state-space modeling with spatially heterogeneous dynamical noise variances, since models with spatial and temporal homogeneity fail to describe the dynamical complexity of brain activity. First, RSTKF is tested using simulated EEG data from sources in the frontal lobe, putamen, and thalamus. After that, it is applied to non-averaged interictal epileptic spikes from a presurgical epilepsy patient with focal epileptic activity in the amygdalo-hippocampal complex. The results of RSTKF are compared to those of low-resolution brain electromagnetic tomography (LORETA) and of standard STKF. Results: Only RSTKF is successful in consistently and accurately localizing the sources in deep brain regions. Additionally, RSTKF shows improved spatial resolution compared to LORETA and STKF. Conclusions: RSTKF is a generalization of STKF that allows for accurate, focal, and consistent localization of sources, especially in the deeper brain areas. In contrast to standard source imaging methods, RSTKF may find application in the localization of the epileptogenic zone in deeper brain structures, such as mesial frontal and temporal lobe epilepsies, especially in EEG recordings for which no reliable averaged spike shape can be obtained due to lack of the necessary number of spikes required to reach a certain signal-to-noise ratio level after averaging.