A longer and healthier life with TOR down-regulation: genetics and drugs. (22nd March 2011)

• Record Type: Journal Article
• Authors: Bjedov, Ivana; Partridge, Linda
• Is Part Of: Biochemical Society transactions. Volume 39:Number 2(2011)
• Page Start: 460
• Page End: 465
• Publication Date: 2011-03-22
• Subjects: aging -- autophagy -- metabolism -- stress -- target of rapamycin (TOR) -- translation; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0390460
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Genetic down-regulation of a major nutrient-sensing pathway, TOR (target of rapamycin) signalling, can improve health and extend lifespan in evolutionarily distant organisms such as yeast and mammals. Recently, it has been demonstrated that treatment with a pharmacological inhibitor of the TOR pathway, rapamycin, can replicate those findings and improve aging in a variety of model organisms. The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance.