Amino acid uptake regulation by cell growth in cultured hepatocytes isolated from fetal and adult rats. Issue 2 (April 1992)

• Record Type: Journal Article
• Authors: Leoni, S.; Spagnuolo, S.; Massimi, M.; Terenzi, F.; Conti Devirgiliis, L.
• Is Part Of: Bioscience reports. Volume 12:Issue 2(1992)
• Page Start: 135
• Page End: 141
• Publication Date: 1992-04
• Subjects: amino acid transport -- cell growth -- rat hepatocytes; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF02351218
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Amino acid uptake mediated by system A was studied in cultured fetal and adult hepatocytes, subjected to growth stimulation by EGF and insulin, or to growth inhibition by high cell density. The mitogenic stimulation induced a strong transport increase only in fetal cells, while the cell density-dependent growth inhibition, probably mediated by molecules present on adult hepatocyte membranes, provoked the decrease of amino acid uptake only in the adult cells. The results indicate that the different modulation of amino acid transport by cell growth is dependent on the age and the differentiation stage of hepatocytes.