Effects of acute ambient pollution exposure on preterm prelabor rupture of membranes: A time-series analysis in Shanghai, China. (1st May 2021)

• Record Type: Journal Article
• Authors: Li, Cheng; Xu, Jing-Jing; He, Yi-Chen; Chen, Lei; Dennis, Cindy-Lee; Huang, He-Feng; Wu, Yan-Ting
• Is Part Of: Environmental pollution. Volume 276(2021)
• Publication Date: 2021-05-01
• Subjects: Ambient pollution -- Acute effect -- Preterm prelabor rupture of membranes -- Time-series analysis -- Particulate matter; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2021.116756
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: While the effects of ambient pollutants on adverse perinatal outcomes have been studied, most studies have focused on preterm birth, stillbirth, and low birthweight. Few studies have examined the effects of ambient pollutants on prelabor rupture of membranes (PROM). This study was designed to explore the acute effects of ambient pollutants on both term PROM (TPROM) and preterm PROM (PPROM). We enrolled pregnant women receiving antenatal care between October 2013 and December 2019 at the International Peace Maternity and Child Health Hospital (IPMCHH). The effects of ambient pollutants (including PM2.5, PM10, SO2, CO, NO2, and 8-h O3 ) on TPROM and PPROM were estimated using generalized additive models (GAMs). Exposure-response relationship curves were also evaluated using GAMs after adjustment for confounding factors. Potential lagged effects were examined using various lag models. The data of 100, 200 pregnant women who delivered at IPMCHH were analyzed. The fitted spline curves for PPROM were similar to the temporal trends of PM2.5, PM10, SO2, CO and NO2 but not O3, while those for TPROM were different from the temporal trends of all six air pollutants. An increased risk of PPROM was associated with increased concentrations of PM2.5, PM10, SO2 and CO on lag days 2 and 3, while no association was found between PPROM and daily concentration of O3 . After adjustment for confounding factors, there was a shift in the exposure-response curves, indicating associations between PPROM and PM2.5, PM10, SO2, and CO on lag days 2–3. Interaction effects of PM2.5, PM10, SO2, and CO were also found to increase the risk of PPROM. In conclusion, acute exposures to six critical air pollutants were not associated with an increased risk of TPROM; however, PM2.5, PM10, SO2, and CO were found to interact, increasing the risk for PPROM on lag days 2 and 3. Graphical abstract: Image 1 Highlights: Acute exposure to these air pollutants did not increase the risk of TPROM. PM2.5, PM10, SO2, and CO interacted with each other to increase the risk of PPROM. No relationship between O3 and PROM was observed. Acute effects of 6 critical air pollutants on PROM were first studied in China.