ERK5 and its role in tumour development. (19th January 2012)

• Record Type: Journal Article
• Authors: Lochhead, Pamela A.; Gilley, Rebecca; Cook, Simon J.
• Is Part Of: Biochemical Society transactions. Volume 40:Number 1(2012)
• Page Start: 251
• Page End: 256
• Publication Date: 2012-01-19
• Subjects: angiogenesis -- cancer -- extracellular-signal-regulated kinase 5 (ERK5) -- microRNA (miRNA) -- migration -- oncogene; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20110663
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The MEK5 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module. It has been proposed to play a role in the pathology of cancer. In the present paper, we review the role of the MEK5/ERK5 pathway using the 'hallmarks of cancer' as a framework and consider how this pathway is deregulated. As well as playing a key role in endothelial cell survival and tubular morphogenesis during tumour neovascularization, ERK5 is also emerging as a regulator of tumour cell invasion and migration. Several oncogenes can stimulate ERK5 activity, and protein levels are increased by a novel amplification at chromosome locus 17p11 and by down-regulation of the microRNAs miR-143 and miR-145 . Together, these finding underscore the case for further investigation into understanding the role of ERK5 in cancer.