Stimuli‐Responsive Nanomaterials for Smart Tumor‐Specific Phototherapeutics. (28th December 2020)

• Record Type: Journal Article
• Authors: Zhou, Bo; Guo, Zhengxi; Lin, Zhaoxin; Jiang, Bang‐Ping; Shen, Xing‐Can
• Is Part Of: ChemMedChem. Volume 16:Number 6(2021)
• Page Start: 919
• Page End: 931
• Publication Date: 2020-12-28
• Subjects: nanomaterials -- phototherapy -- tumor-specific therapeutics -- tumor microenvironment -- targeting; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202000831
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract: Phototherapy, a type of photoresponsive regulation of biological activities, together with additional stimuli‐responsive features, offers significant potential for enhancing the precision and efficacy of cancer treatments. To achieve tumor‐specific therapeutics, numerous studies have focused on the development of smart phototherapeutic nanomaterials (PNMs) that can respond to endogenous pathological characteristics (e. g., mild acidity, the overproduction of glutathione, the overproduction of hydrogen peroxide, the overexpression of specific surface receptors, etc.) present in the tumor and/or exogenous stimuli. Such responsiveness can effectively improve the physicochemical properties, cellular uptake, tumor‐targeting performance, and pharmacokinetic profile of PNMs. Herein, we will systematically discuss recent advances in this field. Moreover, potential challenges and future directions in the development of stimuli‐responsive PNMs are also presented to support the development of this emerging cutting‐edge research area. Abstract : Small, but smart : Smart phototherapeutic nanomaterials (PNMs) that respond to endogenous pathological characteristics and/or exogenous stimulus can be exploited to develop tumor‐specific therapeutics (TST). This Minireview highlights the recent exciting advances in and design rationale of stimuli‐responsive smart PNMs for TST.