Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development. (29th April 2012)

• Record Type: Journal Article
• Authors: Isitman, Gamze; Stratov, Ivan; Kent, Stephen J.
• Other Names: Boesecke Christoph Academic Editor.
• Is Part Of: Advances in virology. Volume 2012(2012)
• Publication Date: 2012-04-29
• Subjects: Virology -- Periodicals; 616.9101
• DOI: 10.1155/2012/637208
• Languages: English
• ISSNs: 1687-8639

Abstract

Abstract : The HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants. It is now also clear that NK cells can also select for immune escape. NK cells force immune escape through both direct Killer-immunoglobulin-like receptor (KIR)-mediated killing as well as through facilitating antibody-dependent cellular cytotoxicity (ADCC). These newer finding suggest NK cells and ADCC responses apply significant pressure to the virus. There is an opportunity to harness these immune responses in the design of more effective HIV vaccines.