Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease. (2nd October 2012)

• Record Type: Journal Article
• Authors: Shimizu, Jun; Izumi, Tomoko; Suzuki, Noboru
• Other Names: Moudgil Kamal D. Academic Editor.
• Is Part Of: Autoimmune diseases. Volume 2012(2012)
• Publication Date: 2012-10-02
• Subjects: Autoimmune diseases -- Periodicals; 571.97305
• DOI: 10.1155/2012/105205
• Languages: English
• ISSNs: 2090-0422

Abstract

Abstract : Behcet's disease (BD) is a multisystemic inflammatory disease and is characterized by recurrent attacks on eyes, brain, skin, and gut. There is evidence that skewed T-cell responses contributed to its pathophysiology in patients with BD. We found that heat shock proteins (HSPs) reactive T cells were prevalent in patients with BD. Here, we summarize current findings on HSP reactive T cells and their contribution to the pathogenesis in patients with BD.