Application of disposable plastic microfluidic device arrays with customized chemistries to multiplexed biochemical assays. (April 2002)

• Record Type: Journal Article
• Authors: Ricco, A. J.; Boone, T. D.; Fan, Z. H.; Gibbons, I.; Matray, T.; Singh, S.; Tan, H.; Tian, T.; Williams, S. J.
• Is Part Of: Biochemical Society transactions. Volume 30:Number 2(2002)
• Page Start: 73
• Page End: 78
• Publication Date: 2002-04
• Subjects: CAE, capillary-array electrophoresis -- CE, capillary electrophoresis -- LIF, laser-induced fluorescence; DNA sequencing -- enzyme assay -- gene expression -- lab on a chip -- protein analysis; Biochemistry -- Congresses; 572
• DOI: 10.1042/bst0300073
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Plastic microfluidic array platforms and synergistic multiplexed assay chemistries are under development for a variety of applications, including assays of gene expression, proteomics, genotyping, DNA sequencing and fragment analysis, sample prepraration and high-throughput pharmaceutical discovery. The low production costs of plastic substrates makes possible economical single-use device arrays, eliminating cleaning and sample-to-sample carryover contamination. Hundreds of microchannels and reservoirs are readily included on a single microtitre-plate-size substrate, enabling the manufacture of highly parallel fluidic array systems to increase throughput and speed.