Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray Radiation. (18th February 2021)

• Record Type: Journal Article
• Authors: Nguyen, Duy Ngoc; Van Dang, Phu; Le, Quoc Anh; Kim Nguyen, Lan Thi; Nguyen, Hien Quoc; Thu Tran, Ngan Thi; Le Bao Tran, Ha; Phan, Tuan Dinh; Bui, Ha Manh
• Other Names: Gawdzik Barbara Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2021(2021)
• Publication Date: 2021-02-18
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2021/6635022
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : Owing to their excellent bioavailability, high bioactivity, and low toxicity, selenium nanoparticles (SeNPs) are emerging nanomaterials. In this study, SeNPs with a size of ∼41.8 nm were synthesised by γ -irradiation using oligochitosan (OCS) as the stabiliser. As-synthesized SeNPs/OCS were characterised by UV-Vis spectroscopy, transmission electron microscopy, and energy-dispersive X-ray (EDX) analysis. Results revealed that the as-obtained SeNP/OCS powder exhibits high purity. The SeNP/OCS solution's stability test results indicated that the SeNP/OCS solution stored at 4°C exhibits good stability for 60 days. The SeNP/OCS solution was unstable at ambient temperature, and SeNP/OCS exhibited agglomeration after about 15 days. SeNP/OCS products recovered the total white blood cells of γ -ray irradiated mice. The SeNP/OCS product, which was synthesised by a green approach, with high purity and efficient recuperation of white blood cells, can be used potentially as a functional supplement to assist cancer radiotherapy patients.