Changes in T-cell subpopulations in mice during prolonged experimental secondary infection with Echinococcus granulosus. Issue 4 (August 1995)

• Record Type: Journal Article
• Authors: Rueda, M. C.; Osuna, A.; De Rycke, P. H.; Janssen, D.
• Is Part Of: Bioscience reports. Volume 15:Issue 4(1995)
• Page Start: 201
• Page End: 208
• Publication Date: 1995-08
• Subjects: Echinococcus granulosus -- hydatidosis -- flow cytometry -- lymphocytes-T -- splenocytes -- thymocytes -- IL-2 receptor -- CD3-CD4-CD8-CD25; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01540454
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Balb/c mice were infected intraperitoneally with protoscoleces of Echinococcus granulosus . After 15 months of infection, and by means of flow cytometry, the expression of T-cell markers CD3, CD4, and CDS on T cells from peripheral blood, spleen, and thymus was analyzed and compared with that of age-matched controls. Infected mice had higher percentages of CD3+, and CD4+ cells in peripheral blood, and higher percentages of CD8+ cells in the spleen, when compared with control mice. CD4+ and CD8+ cells in peripheral blood and CD8+ cells in thymus also showed higher percentages of expression of interleukin-2 receptor. The results infer a role for interleukin-2 in experimental secondary echinococcosis.