Early Gastrointestinal Progression to Immunotherapy in Lung Cancer: A Report of Two Cases. (1st March 2021)

• Record Type: Journal Article
• Authors: Martorana, Federica; Lanzafame, Katia; Pavone, Giuliana; Motta, Lucia; Motta, Gianmarco; Inzerilli, Nicola; Carciotto, Rosaria; Vecchio, Giada Maria; Zanghì, Antonino Maria; Parra, Héctor Josè Soto; Magro, Gaetano; Vigneri, Paolo
• Other Names: Mayordomo Jose I. Academic Editor.
• Is Part Of: Case reports in oncological medicine. Volume 2021(2021)
• Publication Date: 2021-03-01
• Subjects: Oncology -- Periodicals; Tumors -- Periodicals; Oncology -- Case studies -- Periodicals; Neoplasms; Oncology; Tumors; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.994
• DOI: 10.1155/2021/6692538
• Languages: English
• ISSNs: 2090-6706

Abstract

Abstract : Intestinal and pancreatic metastases are rare and often challenging to recognize and manage. Lung cancer patients with enteric involvement usually display poor outcomes. Hyperprogression to immunotherapy represents a concern, even though there is currently no agreement on its exact definition. Gastrointestinal hyperprogression to immune checkpoint inhibitors has not been described so far. In these cases, distinguishing disease-related symptoms from immune-related adverse events may represent a diagnostic conundrum. Here, we report two cases of non-small-cell lung cancer experiencing a rapid pancreatic and colic progression to immunotherapy, respectively. While further investigations to identify biomarkers associated with hyperprogression are warranted, clinicians should be aware of the potential unusual clinical presentations of this phenomenon.