Regional Cerebral Cortical Atrophy is Related to Urinary Tract Symptoms in Parkinson's Disease. Issue 2 (3rd February 2021)

• Record Type: Journal Article
• Authors: Roh, Haewon; Kang, June; Hwang, Soon‐Young; Koh, Seong‐Beom; Kim, Jong Hyun
• Is Part Of: Journal of neuroimaging. Volume 31:Issue 2(2021)
• Page Start: 363
• Page End: 371
• Publication Date: 2021-02-03
• Subjects: Cortical thinning -- nonmotor symptom -- Parkinson' disease -- precuneus -- urinary symptoms; Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/jon.12829
• Languages: English
• ISSNs: 1051-2284

Abstract

ABSTRACT: BACKGROUND AND PURPOSE: Lower urinary tract symptoms (LUTS) are the most common nonmotor symptoms usually occurring mid‐stage of Parkinson's disease (PD); however, its underlying mechanisms are unknown. We aimed to assess whether corticometry or volumetry can identify a pattern of cerebral cortical changes in PD patients with LUTS. METHODS: We recruited 85 idiopathic PD patients and performed corticometry and volumetry on various cortical regions using each patient's magnetic resonance imaging. To identify a correlation between the cortical thickness/volume and nonmotor symptoms scale domain 7 scores, which represent the severity of LUTS, we performed general linear model and region of interest analyses. RESULTS: Significant regional thinning of the left precuneus, left temporal pole, left precentral, right precuneus, and right pars opercularis was correlated with nonmotor symptoms scale domain 7 scores. We also found that cortical volumes of left precuneus and left frontal pole were inversely correlated with the severity of urinary symptoms. CONCLUSIONS: This study showed that the thicknesses and volumes of several cortical regions were significantly correlated with the severity of LUTS in PD patients. The findings of regional atrophy and thinning of specific cortical regions in this study provide additional evidence that multiple cortical regions, especially the precuneus cortex, not only may be involved in urinary dysfunctions of PD patients but also may help to elucidate the exact underlying mechanisms for LUTS in PD patients.