HSP70 and lysosomal storage disorders: novel therapeutic opportunities. (24th November 2010)

• Record Type: Journal Article
• Authors: Petersen, Nikolaj H.T.; Kirkegaard, Thomas
• Is Part Of: Biochemical Society transactions. Volume 38:Number 6(2010)
• Page Start: 1479
• Page End: 1483
• Publication Date: 2010-11-24
• Subjects: acid sphingomyelinase -- heat-shock protein 70 (HSP70) -- lysosomal storage disease (LSD) -- lysosome -- Niemann–Pick disease; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0381479
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Lysosomes, with their arsenal of catabolic enzymes and crucial metabolic housekeeping functions are experiencing a revived research interest after having lived a rather quiet life for the last few decades. With the discovery of the interaction of the lysosomes with another ancient component of cellular homoeostasis, the molecular chaperone HSP70 (heat-shock protein 70), the stage seems set for further discoveries of the mechanisms regulating cellular and physiological stress responses to otherwise detrimental challenges.