Exploring Nature's plasticity with a flexible probing tool, and finding new ways for its electronic distribution. (April 2002)

• Record Type: Journal Article
• Authors: Beier, M.; Baum, M.; Rebscher, H.; Mauritz, R.; Wixmerten, A.; Stähler, C. F.; Müller, M.; Stähler, P. F.
• Is Part Of: Biochemical Society transactions. Volume 30:Number 2(2002)
• Page Start: 78
• Page End: 82
• Publication Date: 2002-04
• Subjects: SNP, single nucleotide polymorphism; gene expression profiling -- genotyping -- in situ synthesis -- microarray -- microfluidics; Biochemistry -- Congresses; 572
• DOI: 10.1042/bst0300078
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Concepts and results are described for the use of a single, but extremely flexible, probing tool to address a wide variety of genomic questions. This is achieved by transforming genomic questions into a software file that is used as the design scheme for potentially any genomic assay in a microarray format. Microarray fabrication takes place in three-dimensional microchannel reaction carriers by in situ synthesis based on spatial light modulation. This set-up allows for maximum flexibility in design and realization of genomic assays. Flexibility is achieved at the molecular, genomic and assay levels. We have applied this technology to expression profiling and genotyping experiments.