Fabrication of an injectable iron (III) crosslinked alginate-hyaluronic acid hydrogel with shear-thinning and antimicrobial activities. (15th May 2021)

• Record Type: Journal Article
• Authors: Shuai, Fangyuan; Zhang, Yanan; Yin, Yijia; Zhao, Hang; Han, Xianglong
• Is Part Of: Carbohydrate polymers. Volume 260(2021)
• Publication Date: 2021-05-15
• Subjects: Alginate-hyaluronic acid ionic-crosslinking hydrogel -- Shear-thinning characteristics -- Injectability -- Antimicrobial property; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.117777
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Fe 3+ complex was used as crosslinker for the alginate-hyaluronic acid hydrogel. This hydrogel displayed outstanding shear-thinning property and injectability. The release of Fe 3+ from the hydrogel provide antimicrobial activities. Abstract: The combination of alginate, hyaluronic acid and multivalent ions have been reported to form alginate-hyaluronic acid ionic-crosslinking hydrogels for biomedical applications. However, injectable alginate-hyaluronic acid ionic-crosslinking hydrogels with satisfactory shear-thinning property have rarely been reported. In this study, we successfully developed an ionic-crosslinked alginate-hyaluronic acid hydrogel by simple assembly of alginate-hyaluronic acid mixture and Fe 3+ complex. This hydrogel could fully recover within seconds after damaged, while displayed shear thinning behavior and good injectability which were contributed by the reversible and dynamic metal-ligand interactions formed via ferric ions and carboxyl groups of the polymers. Moreover, the local degradation of this hydrogel giving the hydrogel sustained ferric ions release property, of which led to potential long-term antibacterial activities against multiple types of bacteria including gram-negative Escherichia coli and gram-positive Staphylococcus aureus, as well as representative oral pathogenic bacteria Streptococcus mutans and Porphyromonas gingivalis .