Novel multifunctional adenine-modified chitosan dressings for promoting wound healing. (15th May 2021)

• Record Type: Journal Article
• Authors: Deng, Pengpeng; Jin, Wenyi; Liu, Zilin; Gao, Mingyong; Zhou, Jinping
• Is Part Of: Carbohydrate polymers. Volume 260(2021)
• Publication Date: 2021-05-15
• Subjects: Chitosan -- Adenine -- Wound dressing -- Antibacterial activity -- Cell proliferation; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.117767
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: Water-soluble adenine-modified chitosan (CS-A) derivatives were synthesized. CS-A derivatives display excellent antibacterial activity, hemocompatibility and cytocompatibility. CS-A sponges exhibit high porosity and good SWF uptake ability. CS-A sponges with high degree of substitution can significantly accelerate wound healing. Abstract: Wound healing is a dynamic and intricate process, and newly dressings are urgently needed to promote wound healing over the multiple stages. Herein, two water-soluble adenine-modified chitosan (CS-A) derivatives were synthesized in aqueous solutions and freeze-dried to obtain porous sponge-like dressings. The novel derivatives displayed antibacterial activities against S. aureus and E. coli . Moreover, CS-A derivatives demonstrated excellent hemocompatibility and cytocompatibility, as well as promoted the proliferation of the wound cells by shortening the G1 phase and improving DNA duplication efficiency. The ability of CS-A sponges to promote wound healing was studied in a full-thickness skin defect model. The histological analysis and immunohistochemical staining showed that the wounds treated with CS-A sponges displayed fewer inflammatory cells, and faster regeneration of epithelial tissue, collagen deposition and neovascularization. Therefore, CS-A derivatives have potential application in wound dressings and provide new ideas for the design of multifunctional biomaterials.